If you are cutting 48 to 60 Rc steel , or hanging the tool 50mm from the holder, then you will see a difference
Otherwise you will not notice anything.
The only advantage of the 1616 tooling is in most cases, it has the range of tools most used in industry as a standard sized insert. This will give you a greater range of insert geometry types, like the TNMG1604 range or the DCMT11 range or the CCMT09 or the VNMG16.
Neil