I assume he means the Uniloc quick release as opposed to a Radial pin. I'll go on this assumption to answer.
Going from a wood/wood connect to a piloted/insert changes two main factors.
First, the connection of the metal pin into wood goes to a metal pin into a brass insert. That means less contact between the butt and the shaft. The face also changes because the brass insert has a pilot. The overall contact of the face diminishes.
Second, you are adding mass to shaft due to the insert. I will say the difference in weight between the two pins is negligible.
Now, do I believe that, say, a 3/8-10 is better than a Uniloc connection? Not necessarily. Do I believe a wood/wood joint is better than pilot/insert? Not necessarily. To each his own. The OP's question is "would the hit change?" The simple answer is yes.
I usually ask why he wants it changed. If it is convenience, I say do not do it. If it is he prefers the hit compared to the original configuration, I say go for it.
Did I help?