After staring at this for a long time, I've come to the conclusion that you're not going to run it out.
If the 6-ball goes, then this is a runout table.
Obviously, the key is to break out the 6-ball, if it doesn't go. But, the 2-ball isn't great for a 6-ball breakout. And if the table is any tight, the 2-ball is just tease. You need to come across the 6-ball without trapping it there (double kiss) or without tickling the 8-ball. If either of these happens, then not only do you put yourself in just as bad a position, but it could end up actually worse. I think you're 70/30 to get bad after attempting to break out the 6-ball. I think this is a sucker shot that's going to end up in misery and a crap shoot in the end.
So, I'd go for the whole ball of wax by clearing out the 3/5, and playing for a bank on the 6-ball without disturbing the 8-ball. So, maybe 3/5 combo, 2-ball (trying to play for the 6-ball bank). And then it's clear. I think the key to clear the 6-ball without disturbing the 8-ball to at least give you the advantage if you miss the 6-ball.
Fred