The Safest way is to first make sure that the person you are dealing with has a current and verifiable reputation of being aboveboard. The method of payment should be secondary to the verifying the currency of their reputation. A seller with no previous deals will only get paid if he is willing to ship first for my inspection or ship to an escrow agent for me. I do not care if he is selling something valued at $1000 for only $200. I need proof he can be contacted and is verifiable. ebay scams are fairly easy to pick out from the crowd just by looking at the feedback, feedback dates, and when the last verifiable transaction occured. If the person is legit and I am comfortable with them, I will send them a money order or cashiers check if they like, no big deal. The method of payment is really a non-issue with my transactions because I verify the seller or I don't buy from them, period. I recently cancelled a deal after I discovered that the seller had not sold anything in over a year, and that Paypal listed their Paypal account as "unverified". Big red flags went up with it being an unverified account and I backed out. I then discovered the seller was using a copy of another company's listed pictures for the same item. The seller never contacted me, even though I sent a message to them to contact me with an explanation of their unverified account if they wanted to complete the deal. It has been 2 weeks and I haven't heard a reply or demand for payment. It appears that it was a scam auction.
When selling, make sure of their current rep is verifiable and recent as well. Place limitations on your side based on their location, ability to be contacted, and what you are willing to do to secure the deal. Always ship and get signature oconfirmation by insuring the item for over $200 if shipping through the postl service. Never ship to certain countries such as Indonesia. Require payment be either Paypal, postal money order, or bank cashiers check. Never ship until the funds have cleared into your bank account unless you are completely confortable with the buyer and their reputation. I have dealt with people on eBay that I was so comfortable with that I shipped before receiving payment just based on their solid and current rep and sometimes having done business with them before. Some I have elected to accept personal checks from and shipped the day I received the check. Know your seller or buyer. That is the key. I have not been burned, but have burned many a scammer.