Almost certainly. Like it was in a major championship/tournament and something very remarkable happened seven moves later. Like the surprise move changed the status of that opening forever.Here is the original video with Magnus. The comments discuss this a little. That opening has been played tens of thousands of times. Probably he guessed because the game was notable for some other reason. ...
Chess positions have many more "interconnections" than positions at pool. The knight being on that square has special offense and defense aspects. Move it a square, and it becomes irrelevant.