Huge difference in my mind
I have kept my cue purchases over the years to used customs from plain Jane playing cues on up to somewhat fancy $2K-3K customs (retail value). I have also owned and played with all of the standard production label Meucci, McDermott, Viking, Schon, Players, Lucasi, etc etc etc. Other than one old Original Meucci I owned, I can't remember any production cue as having a spectacular hit or balance worth noting. Not so for the customs I have owned and played with. Of course there have been some customs I downright disliked for some playability reason or another and couldn't wait to unload at whatever price I got for them.
What I have observed in my world:
If you buy a new production cue for $400, you're lucky if you can to sell it for $150 used in 2-5 years. If you buy a used production cue for $150, you might be able to sell it for $150-200 in the future if you bought it right. Old Meucci Originals and McDermott C & D series are an exception.
Buy a used custom cue at whatever price. You get a cue that may have cost you more up front, but if you did your homework, you got a decent deal, and now have a cue that is tried and true, isn't warped like many old production cues I have seen, plays and balances great possibly giving you more confidence in your stroke, and is easier to resell for more than you paid for it day one. Also, like it or not, you get total strangers walking up to you from across the room complimenting your cue and asking to look at it.
Here is just a few examples of "Strictly Hypothetical" cue turns one could have achieved in the past.
Mottey - standard 4 point veneered leather wrap purchase for $860 sell for $1000 1 yr later.
Mottey ivory joint amboyna point lizard wrap - pay $1350 sell for $1875 6 months later.
Dishaw 4 shafts - pay $1000 - sell for $1675 6 months later
3 Cognoscenti plain janes - pay $600, $750, $800 sell for $900, $1000, $1000 4 months later
New Runde 2000 Pay $1125 sell for $1750 6 months later
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I never found a production cue that hit anything played or felt like any one of the cues mentioned in the hypothetical example.
I personally lost money selling used production cues and if the hypothetical list of transactions above were possible, I see no reason to waste my money buying a production cue. I did sink more into my Les Blevins than what I would have liked to, but this baby hits better than any of those listed above, so I don't see it going anywhere for a long time. Meucci? No Way.