Shoot the 12 and leave the cueball below the 5 for a shot on the 13 or 15 in the side. Then leave the cueball between where the 13 and 15 are to shoot the 10 and go for the breakout of the 2, 14 and 11. It's a little risky but if the 14 doesn't end up on the rail behind the 5 you should get out.
If playing safe is the plan, I don't like shooting off my ducks while that 2 ball is still in trouble. I'd shoot in the 6 to establish solids, then play safe by hitting the 7 up table (to become a helper later) and freeze the CB behind the 3.