I rarely play 14.1, but I think I'd go with follow, bust the pack a bit, and set up a shot into the lower right corner.
Prayers to George...
Play the One Ball with 2 tips low right and a good stroke.
Strike the 15 ball dead center and pull the cue ball back about 10 inches toward the center of the table. This drives the 6 into the corner and separates the rack nicely for the run out.
There's a good chance you might make the 4 ball as well.