Absolutely, 100% there is such a thing a natural talent. Amongst probably a few other core things, here are two that are applicable directly to pool-
Kinesthetics.This is the awareness of where you body is in space, and what it is doing. This is a function of how well the brain interprets the signals coming from the limbs, and other parts of the body. People on the operating table who report "out of body experiences"? This is the kinesthetics function going haywire due to lack of oxygen, or in the case of brain surgery, direct stimulation of that portion of the brain. This literally makes the brain think their "consciousness" is floating outside of the body. This is a simple signalling error. Teenagers start stumbling over themselves during growth spurts, because the kinesthetics system is getting signal errors, or misinterpreting inconsistent signals from the muscles. If it can happen naturally during puberty, it can happen because of weak genetics.
Now think about people who were born with 100% accurate kinesthetics. They will intuitively know when they miss a shot, what their bodies were doing at the time, and they have a much more solid basis to know what to do to fix it... Which leads to #2..
Muscle memory. This is the ability of the muscles to "burn-in" repeated motions, building stronger neuronal connections through the brain related to that motion. Some people (like me) have weaker muscle memory, and as such, have to practice hours and hours in order to build the muscle memory, and then it fades fast, requiring more practice. And even then, if you have bad kinesthetics, the signals may still get crossed, causing huge amounts of inconsistency, even with loads of practice. Superpros almost invariably have nearly perfect muscle memory, and very very good kinesthetics. Otherwise.. Explain how the heck Bustamente can play as well as he does bridging a mile from the cue ball, and with that stroke?
As an aside, this muscle memory applies to playing of a musical instrument, as well. I see the same muscle memory issues when practicing guitar, as I do when trying to correct my pool stroke. I have seen stories in this very forum where someone mentions an extremely talented teenager who gave up the game to play guitar, as it got more girls, and became just as talented, extremely quickly. There is a physical reason for this. Stories abound of this and that guitar god who picked up a guitar and we're within months able to do things it took other players years to do.
Add to this, some people simply don't feel pressure the same, and don't dump a load of adrenaline in a dangerous situation. A good test of this is when you are driving down the road, and your car drifts a little to the center line just as another car is coming.. If you have an immediate adrenaline surge and your heart beats faster, then you probably are the type that feels immense pressure on the tough shot, hill-hill. To the point where your heart is beating out of your chest. That adrenaline surge seriously f*cks up fine motor control. Some folks, this "fight or flight" adrenaline surge gets worse as they age. Some, the response goes away completely, allowing them to play pretty damn sporty into their 50s. It's all genetic.
That's my scientific take on "natural talent". As a young, aggressive man who thought he could do anything, I too thought natural talent was a myth. What changed my mind was reading an old chess book in which a master player walked through the core brain mechanisms that absolutely put a limit on the ability of a chess player. One of those was pattern recognition. Another was ability to move pieces in their mind, and retain new positions in their head. These are both 100% genetic, and can only improve a minor amount if you "don't got it". He even laid some tests out for how to determine where one was on the scale. We KNOW that pattern recognition is either genetic, or biochemical, because of it's pronounced manifesting in people with certain mental illnesses.. Seeing patterns everywhere, even where they don't exist.
This led me to think about why there are "natural athletes" that can switch from one sport to another when young, and dominate in both, with minimal training. And I came to a personal determination that physical talent can very well limit top potential in many games/sports. But specific physical talents make it MUCH easier to cross over to new games that require the same basic physical talents.