As long as there is enough "meat" on the Titlist blank, there really is no difference as far as time and difficulty go, but the final product is much nicer and will have more market value if you use a Titlist rather than a plain full spliced "sneaky" blank. Probably most Titlist conversions done have an 'A' joint installed, which does differentiate them from a sneaky conversion which will be a one piece butt, but not all.
As far as doing a Titlist from a new blank, a "Titlist" cue is a very specific cue. Titlist was the name given to Brunswick's four veneer cue from the early 1940s thru the 70s. Prior to that it was known as the model 26.5, and then briefly as the Carom King, and I have original examples of each. It always has four points, and four veneers of maple, mahogany, teal, and purple. If you make your own "new blank" it's then called a Titlist tribute. I'm making a couple now using Martin's repro veneers and curly maple rather than straight grain. They'll be very nice, but still tributes, not true Titlists.
If you think about it, the Brunswick Titlist is probably the single most influencial cue in history. With it's full spliced construction, sharp points, and colorful veneers, I believe that it set a standard for cue making that many still cannot replicate even now, 100 years later. Titlist blanks were used at some time by most, if not all, of those that we consider the masters of cue making. I have examples nearly 100 years old that have points as sharp and even (on both ends) that can possibly be made by human hands.
Mr H