Looks like you're playing the carnival game of three ball here, so the stop shot and then the safety is not an option. Mark's shot in post 16 is a good idea, although getting the speed right is no bargain, but if I had to run out here, I'd rather bank the two than try to make good shape onto the two.
PS I guess you could possibly be playing 14.1 here. If so, stop shot and then safety off the left edge of the three. You could also be playing bank pool, but then you must play safe right now. Can't think of any other game in which the one, two and three can be the last three balls on the table, although I suspect there are others.