Well...
I have personally watched Karen bust up Mika on the JOSS and almost make him cry. (By the way GMAC, JOSS is also winner breaks)
She's beaten a lot of the top men that ever played on that tour and won her fair share of events over the years.
Other names names like Rempe, Zuglan, Lapena, Saez, San Souci, Hernandez, Basavich, Korsiak, Immonen, Sambajon, Vierra come to mind, as staples of that tour back then.
So it's not like she is totally unprepared to compete with men.
I don't know if any woman is capable at this point of winning the whole thing, but i would fully expect some "upsets" to happen vs. some of the top women along the way to finding out.
Actually, i think that Karen plays WAY better against the men, then she ever did against the women, but that's just my own personal opinion.
It would also be interesting to see how many new and improved sharking techniques will surface at the Open, when some men are getting their nuts BBQed by some female and are facing possible elimination.
We all know that some of the egos out there, aren't going to be able to fade that at all.
It will be entertaining to say the least.